Anticancer Activity of Copper-Chitosan Nanocomposite Conjugated with Folic Acid

Folic acid (FA) is used as target drug delivery for cancer cells by adding to copper/chitosan nanocomposite (Cu/CNC) form FA-Cu-CS complex. Chitosan a promising polymeric that has received lot of attention recently. nanoparticles have wide applications nanocarrier different organic and inorganic substances. In the present study, chitosan (CNP), Cu/CNC, had been prepared characterized. Structural, morphological, optical anticancer activities were studied. X-ray diffraction study showed formation CNP, FA-Cu-CS. FE-SEM CNPs spherical shape. While, image Cu/CNC aggregated semi-spherical shapes, but aggregated, agglomerated, irregular shapes. FTIR analysis resulted peak at 1026.13 cm–1 refer bonded with folic acid. UV/VIS spectroscopy absorbance 530 nm due presence Moreover, activity CNPs, was tested MTT assay against fibroblast, MCF-7 ovarian cancer, then it stained DAPI show morphology nucleus. higher cytotoxicity from other which 54%, 65% 83% respectively concentration 0.175 μL/mL. To our knowledge, there no report on enhancing conjugated comparison among